4D Path, PathPresenter Announce Partnership to Advance AI-enabled Digital Pathology for End-to-End Breast Tumor Profiling


Montville, New Jersey, and Newton, Massachusetts, March 15, 2022PathPresenter, a pioneer in the development of digital pathology software, and 4D Path Inc., developer of a pan-cancer diagnostic and precision oncology platform enabling AI-based biomarker typing and prognostication from H&E images, are announcing today a global partnership to distribute 4D Q-plasia OncoReader Breast within PathPresenter’s new Clinical Workflow Platform, ClinPx.

4D Q-plasia OncoReader Breast provides histopathologists with an adjunct technology to potentially improve diagnostic accuracy of breast cancer features (e.g., its invasiveness, grades, ki-67 status, etc.) solely from digitized histopathology images obtained via biopsies or resections. Through this partnership, pathologists will have the ability to run the 4D Q-Plasia OncoReader Breast directly within the ClinPx whole slide image viewer. Embedding this AI technology within PathPresenter’s emerging ClinPx platform – a scanner-agnostic digital pathology workflow solution – could accelerate the adoption of AI tools within clinical workflows.

“We believe that the integration of these two technologies will redefine how AI can be adopted by everyday pathologists,” said Rajendra Singh, M.D., Founder of PathPresenter.

The primary purpose of integrating 4D’s proprietary algorithms within the ClinPx platform is to potentially improve the throughput, reliability, and quality of consultations provided by physicians. Additionally, users from pharmaceutical organizations could also benefit from the enablement of the standardized central pathology review of certain biomarkers within the context of clinical trials leveraging the ClinPx platform.

“This unique partnership is very much needed to make the most of the increasing investment in digital pathology,” said Tathagata Dasgupta, Founder and President of 4D Path. “While PathPresenter offers a software platform made by pathologists to serve pathologists in their digital workflow, it will have at its heart the 4D Path-driven end-to-end tumor profiling white-box solution that can produce synoptic reports to potentially assist clinical reporting.”

To advance the adoption of digital pathology worldwide, 4D Path and PathPresenter have created exclusive educational content to teach current and future pathologists about how evaluation of breast cancer features prior to downstream genomic and molecular testing can potentially improve patient care. This information will be available to PathPresenter’s 40,000 global users at PathPresenter.net.

*4D Q-plasia OncoReader Breast has not been approved by the FDA or the EMA for primary diagnosis. 4D Q-plasia OncoReader Breast is for Research Use Only (RUO)

About PathPresenter

PathPresenter has been a pioneer in the development of digital pathology software since 2017. Originally known for its education platform, PathPresenter has evolved into a suite of interconnected digital pathology products that enable the use of digital pathology images for clinical care, medical education, and research. With over 40,000 registered users adopting its technologies around the world, PathPresenter enables a global clinical and data network for AI-driven precision medicine to define a new standard of care. Visit https://pathpresenter.net/ to learn more.

About 4D Path

4D Path’s mission is to democratize precision diagnostics and oncology by unveiling previously hidden information purely from cellular snapshots of tissue (e.g., histology) or liquid (e.g., cytology) without the use of antibody stains. The company’s cloud-based 4D Q-Plasia OncoReader (QPOR) is a U.S. patented pan-cancer precision diagnostic and oncology platform which is being designed to extract diagnostic data from routine cytology and histology images. Its beachhead product, the 4D QPOR Breast, has been awarded FDA Breakthrough Device Designation for potentially improving diagnostic accuracy over the current standard of care. This end-to-end solution provides an adjunct tool, which aims to accelerate diagnostic turnaround times, reduce cost, and improve diagnostic accuracy in a single step. In addition, this technology is being designed to identify an overall biologic cancer signature to guide therapeutic management from as early as pre-treatment biopsy/resection specimens. This single test will not require the multiple additive signatures that multi-omics platforms depend upon, with their additional burdens of cost, diagnostic delay, and reliance on specialized equipment. This approach toward tumor profiling could lead to the 4D QPOR becoming an efficient and universally accessible platform to better predict and stratify patient response to therapy. The platform can integrate seamlessly into any existing clinical workflow without altering current practices. Visit https://4dpath.com to learn more.

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