partnerships@4dpath.com

Our Science

4D Path is fueling future advances in cancer therapeutics with its QPOR™ platform, which is designed to accurately predict a patient’s response to cancer treatment from digitized images of a standard H&E-stained biopsy.

  • Using a unique combination of statistical physics and a deep understanding of cancer biology, 4D Path’s technology can directly measure and quantify cell cycle deregulations, a hallmark of cancer’s unregulated cell growth. Prior to 4D Path, no other technology has been able to measure these intra/inter tumor dynamics.
  • Unlike existing cancer diagnostics which infer potential response based on molecular driver(s) of disease, this approach accounts for and quantifies the impact of complex multi-system interplay that is fundamental to cancer biology.

Cancer is driven by complex interactions within biological systems, yet current diagnostic methods measure molecular drivers of disease as tumor markers to infer response to therapy.

By comparison, 4D Path takes a systems approach by capturing the collective biological signature from cell cycle deregulation and tumor immune microenvironment indices for direct therapy response prediction.

4D Path QPOR™ Platform Deeper Dive

QPOR™ Uses the Laws of Physics to Retrieve and Build Biological Signatures in a Heterogeneous Environment

Digitized Image

Unique interpretation of H&E image as a snapshot of cycling cells in various phases of cell cycle, uses statistical physics to retrieve those cycles, uncovers hidden information

Dynamics

Relates the attributes of single cells to the population of cells seen in the tissue Identifies cell cycle dynamics

Biological Signature

Extracts unique pan-cancer effective biomarkers

Heterogeneity

Captures tumor heterogeneity and oncogenic vulnerability Predict drug response and resistance

Broader use

Broad applicability across cancers

4D Path Solution

Drive Innovation to Fulfill the Unmet Needs and Simplify Processes

01.

Digitized H&E-stained biopsies

02.

Cloud-based cancer predictive platform

03.

A Comprehensive Report with Tumor Response Prediction, and additional diagnostic and prognostic profiles

04.

Treatment Decisions, Cohort Selection and Optimization

Our scientific workflow
Cancer is driven by complex interactions within biological systems, yet many methods measure molecular drivers of disease as tumor markers and fall short of predicting how patients respond to treatments.
4D Path takes a systems approach and identifies biological signatures or “effective biomarkers” of direct tumor response to predict effective treatments using digital images of standard H&E-stained biopsies.